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Rodent Tethered Infusion Systems

Tethered systems require an in-dwelling catheter, a harness or jacket, spring tether, swivel, swivel holder, extension lines and infusion pump. In the past, the fluid-carrying components of these systems (the catheter, extension lines and swivel) were all connected by friction fitting a stainless steel cannula with the internal diameter of flexible polymer tubing. New catheter and harness designs have made the entire process more reliable and less time-consuming. Today, the most advanced system available, the patented Quick Connect™ system, eliminates all of the sizing issues inherent in older systems and replaces the friction connections with secure luer locks. These fittings can be connected and disconnected quickly and cleanly allowing for intermittent infusion and sampling without continuous tethering or restraint. Highquality polyurethane has become the preferred catheter material due to its pliability and thromboresistant nature. Recent tapered catheter designs greatly increase success rates, allowing for smaller diameter distal ends that insert easily into vessels and thicker walled proximal ends that connect directly to the harness or swivel.


Insulin & Glucose Clamp System

SAI carries a complete set of components for researchers using the Glucose, or Insulin Clamp Technique (sometimes called euglycemic or hyperinsulinemic clamp) in rodents to assess Insulin Sensitivity. These clamp methods are typically employed in research designed to measure the effects of test agents or other types of interventions on metabolic disease. These systems require specialized infusion and sampling components to ensure meaningful data collection. Dual infusion lines for glucose and insulin, as well as a separate sampling line for blood measurements are often used concurrently in these complex systems. Accurate and easy-to-use syringe pumps are also essential in these studies, as the rate of infusion may be frequently adjusted throughout the Clamp procedure. When designing a clamp system for your research, please contact the experienced scientists at SAI to help select the appropriate components to meet your metabolic research needs.